Middle East respiratory syndrome coronavirus (MERS-CoV): A review
Identifieur interne : 000646 ( Main/Exploration ); précédent : 000645; suivant : 000647Middle East respiratory syndrome coronavirus (MERS-CoV): A review
Auteurs : Nour Ramadan [Liban] ; Houssam Shaib [Liban]Source :
- Germs [ 2248-2997 ] ; 2019.
Abstract
As a novel coronavirus first reported by Saudi Arabia in 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV) is responsible for an acute human respiratory syndrome. The virus, of 2C beta-CoV lineage, expresses the dipeptidyl peptidase 4 (DPP4) receptor and is densely endemic in dromedary camels of East Africa and the Arabian Peninsula. MERS-CoV is zoonotic but human-to-human transmission is also possible. Surveillance and phylogenetic researches indicate MERS-CoV to be closely associated with bats’ coronaviruses, suggesting bats as reservoirs, although unconfirmed. With no vaccine currently available for MERS-CoV nor approved prophylactics, its global spread to over 25 countries with high fatalities highlights its role as ongoing public health threat. An articulated action plan ought to be taken, preferably from a One Health perspective, for appropriately advanced countermeasures against MERS-CoV.
Url:
DOI: 10.18683/germs.2019.1155
PubMed: 31119115
PubMed Central: 6446491
Affiliations:
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The virus, of 2C beta-CoV lineage, expresses the dipeptidyl peptidase 4 (DPP4) receptor and is densely endemic in dromedary camels of East Africa and the Arabian Peninsula. MERS-CoV is zoonotic but human-to-human transmission is also possible. Surveillance and phylogenetic researches indicate MERS-CoV to be closely associated with bats’ coronaviruses, suggesting bats as reservoirs, although unconfirmed. With no vaccine currently available for MERS-CoV nor approved prophylactics, its global spread to over 25 countries with high fatalities highlights its role as ongoing public health threat. An articulated action plan ought to be taken, preferably from a One Health perspective, for appropriately advanced countermeasures against MERS-CoV.</p></div></front></TEI><affiliations><list><country><li>Liban</li></country></list><tree><country name="Liban"><noRegion><name sortKey="Ramadan, Nour" sort="Ramadan, Nour" uniqKey="Ramadan N" first="Nour" last="Ramadan">Nour Ramadan</name></noRegion><name sortKey="Shaib, Houssam" sort="Shaib, Houssam" uniqKey="Shaib H" first="Houssam" last="Shaib">Houssam Shaib</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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